Calmodulin (CaM) is a ubiquitous, calcium-binding protein that binds and regulates a multitude of protein targets, many of which are involved in the Alzheimer"s and the Parkinson"s pathways^1,4. CaM has a molecular weight of about 17kDa, containing 148 amino acids, and pI of 3.9. CaM is characterized by two domains, connected by an alpha-helix chain. Each domain has the capacity to bind two calcium ions. Binding Ca²⁺ ions causes a conformational change in CaM, making it available for interaction with target proteins. Hence, CaM functions as an intracellular calcium ion bridge to mediate cellular reactions and responds appropriately to calcium ion concentration. In Alzheimer"s disease (AD), irregular calcium homeostasis seems to trigger CaM and its binding proteins, to enhance plaque formation and neurofibrillary degeneration, which results in cell death1. The increased cytosolic levels of Ca²⁺ in AD neurons promotes CaM binding and regulation of available Ca²⁺/CaM-dependent CaM-binding proteins, associated with amyloid beta (Ab) formation. In addition, the increased level of Ca²⁺ triggers Calmodulin to activate calcium/CaM-dependent kinase II and precede neurofibrillary tangle formation^2,4. In Parkinson"s disease (PD), Calmodulin has been found to interact, in a calcium dependent manner, with Alpha-Synuclein, which is associated with the progression of PD. CaM was identified as one of the synuclein-interacting proteins that regulate synuclein conformation³.

rPeptide是一家生物化学公司，坐落于美国乔治亚州，与雅典毗邻。该公司研发试剂是市场领跑者，主要产品涉及领域为老年性痴呆症与帕金森综合症研究使用的重组蛋白，重组多肽，抗体以及试剂等等。 该公司提供一系列外包服务，从分子生物学，蛋白表达与蛋白纯化到13C与15N 统一标记蛋白与多肽。同时， rPeptide 技术平台可解决可溶性多肽/蛋白（例如：β-淀粉样蛋白、廋蛋白、前胰岛素）在大肠杆菌中表达等历史性难题。

rPeptide 主要产品分类

1、Beta淀粉样蛋白 Beta-Amyloid Peptides, Human, Native and Mutant, Recombinant Beta-Amyloid Peptide Fragments Beta-Amyloid Labeled Peptides, Recombinant Beta-Amyloid Labeled Peptides, Synthetic 2、蛋白 Tau Tubulin Synuclein Amyloid Precursor Protein Apo E AD/PD related Proteins Calmodulin 3、标签蛋白 Beta-Amyloid Labeled Peptides, Recombinant Beta-Amyloid Labeled Peptides, Synthetic Labeled Calmodulin Proteins 4、单抗 Beta Amyloid Tubulin Tau and Related proteins 5、多抗 Tau