A potent and reversible serine protease inhibitor (IC50=0.3-54 uM)1. Selectively inhibits human tryptase (Ki = 95.3 pM) when employed at low concentrations2. Dramatically suppresses pulmonary dysfunction in a rat model3 and inhibits airway eosinophilic inflammation4. Anticoagulant, thrombin inhibitor which attenuates neuronal damage in a transient focal cerebral ischemia model5. Also blocks TRPM7 in the absence of extracellular divalent cations6. Cell permeable.