I-BET762 is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF1,2. IC50’s for H4Ac peptide displacement: BRD2=32.5 nM, BRD3=42.4nM, BRD4=36.1nM1. It was able to suppress key inflammatory genes as well as the release of proinflammatory cytokines and prevent acute inflammation in mice1. Suppresses the inflammatory function of T cells3. Inhibition of BET bromodomains results in downregulation of Myc transcription, an important oncogene4.