Antimalarial drug. Inhibits autophagy in a variety of cell lines1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer2. Eliminates cancer stem cells via deregulation of Jak2 and DNMT13. Displays synergy when combined with the Raf inhibitor, vemurafenib, in brain tumors4. Cell permeable and active in vivo.