A necrostatin-1 analog with superior potency2, selectivity3 and metabolic stability at RIP1 inhibition (IC50 = 206 vs 494 nM)1,2. Displays greater efficacy at inhibition of necroptosis in Jurkat cells with no non-specific cytotoxicity (100 nM)2. Ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model4. Recommended for cellular and in vivo applications over necrostatin-15.