Selective inhibitor of Usp14 (IC50<4 µM). Enhances proteasome activity and substrate proteolysis1,2. Inhibits Dengue virus replication3. In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load4. Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model5. Cell permeable.