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主营:单克隆抗体、多克隆抗体、重组蛋白,重组多肽,抗体,标记多肽和蛋白质
℡ 4000-520-616
℡ 4000-520-616
rPeptide/Tau-4G11 Antibody Kit TA-1006/100ug/TA-1006-2
产品编号:TA-1006-2
市  场 价:¥9500.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$475.00
品      牌: rPeptide
公      司:rPeptide,Inc.
公司分类:
rPeptide/Tau-4G11 Antibody Kit TA-1006/100ug/TA-1006-2
商品介绍
Tau is a family of six isoforms, derived from a single gene by alternative mRNA splicing1. They vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa), and differ from one another in having three or four microtubule binding repeats (R) of 31-32 amino acids each, and two, one or none amino terminal inserts (N) of 29 amino acids each2.

Tau promotes the assembly and maintains the structure of microtubules in neuronal cells3,4,5. While the fetal brain contains a single isoform of tau (Tau-352) the adult brain has several isoforms. Tau is both phosphorylated and O-GlcNAcylated6. The normal brain tau contains 2-3 moles of phosphate/mole of the protein. In Alzheimer disease tau is hyperphosphorylated, containing 3-4-fold more phosphate/mole of the protein than the normal tau7,8 and is the major protein subunit of paired helical filaments (PHF) that form the neurofibrillary tangles (NFT). NFT accumulation correlates with the clinical progression of Alzheimer"s disease. Tau 4G11 (TA-1001) is a rPeptide exclusive Tau Monoclonal Antibody that binds 4 out of the 6 Tau isoforms. It specifically binds Tau-381, Tau-410, Tau-412, and Tau-441 which all contain at least one amino terminal insert.

品牌介绍

rPeptide是一家生物化学公司,坐落于美国乔治亚州,与雅典毗邻。该公司研发试剂是市场领跑者,主要产品涉及领域为老年性痴呆症与帕金森综合症研究使用的重组蛋白,重组多肽,抗体以及试剂等等。
该公司提供一系列外包服务,从分子生物学,蛋白表达与蛋白纯化到13C与15N 统一标记蛋白与多肽。同时, rPeptide 技术平台可解决可溶性多肽/蛋白(例如:β-淀粉样蛋白、廋蛋白、前胰岛素)在大肠杆菌中表达等历史性难题。

 
 
  rPeptide 主要产品分类  
 

1、Beta淀粉样蛋白
Beta-Amyloid Peptides, Human, Native and Mutant, Recombinant
Beta-Amyloid Peptide Fragments
Beta-Amyloid Labeled Peptides, Recombinant
Beta-Amyloid Labeled Peptides, Synthetic
2、蛋白
Tau
Tubulin
Synuclein
Amyloid Precursor Protein
Apo E
AD/PD related Proteins
Calmodulin
3、标签蛋白
Beta-Amyloid Labeled Peptides, Recombinant
Beta-Amyloid Labeled Peptides, Synthetic
Labeled Calmodulin Proteins
4、单抗
Beta Amyloid
Tubulin
Tau and Related proteins
5、多抗
Tau

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