A deletion mutant of a-synuclein (amino acids 96-140). Alpha-Synuclein (a-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson's disease aggregates and is implicated in the pathogenesis of Parkinson's Disease and related neurodegenerative disorders. a-Synuclein accumulates in the brains of sporadic Parkinson's disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson's disease. a-Synuclein appears to associate with other proteins that aggregate and is found in a-amyloid plaques and neuritic tangles in Alzheimer's disease,6. This product has been produced without a methionine (M) at the start of the sequence to provide our customers with a more native, physiologically relevant product.